Limited effect of omega-3 fatty acids on the quality of life in survivors of traumatic injury: A randomized, placebo-controlled trial.
Prostaglandins Leukot Essent Fatty Acids
; 127: 1-5, 2017 Dec.
Article
em En
| MEDLINE
| ID: mdl-29156152
ABSTRACT
Empirical evidence is divided on whether n-3 polyunsaturated fatty acid levels are associated with quality of life (QOL). This study investigated the effects of docosahexaenoic acid (DHA) supplementation on QOL in survivors of traumatic injury. In this secondary analysis of a double-blind, randomized controlled trial, we recruited 110 trauma patients (82% men; mean age, 39.6 years) in an intensive care unit. Fifty-three received DHA-rich supplements and 57 received placebo for 12 weeks. We used the Medical Outcomes Study 36-Item Short Form Health Survey (SF-36) to assess QOL at the end of intervention. DHA did not significantly affect any QOL domain on the SF-36 after 12 weeks. In the DHA group, changes in the erythrocyte levels of eicosapentaenoic acid (EPA) + DHA and EPA were positively correlated with the SF-36 mental component. DHA did not influence QOL of trauma patients, but increased EPA levels during the trial were associated with better QOL in patients receiving omega-3.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Ácidos Graxos Ômega-3
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Ácidos Docosa-Hexaenoicos
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Suplementos Nutricionais
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Lesões Encefálicas Traumáticas
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article