Dose Dependencies and Biocompatibility of Renal Clearable Gold Nanoparticles: From Mice to Non-human Primates.
Angew Chem Int Ed Engl
; 57(1): 266-271, 2018 01 02.
Article
em En
| MEDLINE
| ID: mdl-29160029
ABSTRACT
While dose dependencies in pharmacokinetics and clearance are often observed in clinically used small molecules, very few studies have been dedicated to the understandings of potential dose-dependent inâ
vivo transport of nanomedicines. Here we report that the pharmacokinetics and clearance of renal clearable gold nanoparticles (GS-AuNPs) are strongly dose-dependent once injection doses are above 15â
mg kg-1 high dose expedited the renal excretion and shortened the blood retention. As a result, the no-observed-adverse-effect-level (NOAEL) of GS-AuNPs was >1000â
mg kg-1 in CD-1 mice. The efficient renal clearance and high compatibility can be translated to the non-human primates no adverse effects were observed within 90â
days after intravenous injection of 250â
mg kg-1 GS-AuNPs. These fundamental understandings of dose effect on the inâ
vivo transport of ultrasmall AuNPs open up a pathway to maximize their biomedical potentials and minimize their toxicity in the future clinical translation.
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MEDLINE
Assunto principal:
Materiais Biocompatíveis
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Nanopartículas Metálicas
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Ouro
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Rim
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article