Reduction of venous pressure during the resection of liver metastases compromises enteric blood flow: IGFBP-1 as a novel biomarker of intestinal barrier injury.
Clinics (Sao Paulo)
; 72(10): 645-648, 2017 Oct.
Article
em En
| MEDLINE
| ID: mdl-29160429
ABSTRACT
OBJECTIVES:
Disruption of the intestinal barrier and bacterial translocation commonly occur when intestinal blood flow is compromised. The aim of this study was to determine whether liver resection induces intestinal damage.METHODS:
We investigated intestinal fatty-acid binding protein and insulin-like growth factor binding protein levels in the plasma of patients who underwent liver resection.RESULTS:
We show that liver resection is associated with significant intestinal barrier injury, even if the Pringle maneuver is not performed.CONCLUSION:
We propose the use of insulin-like growth factor binding protein-1 as a novel biomarker of intestinal damage in such situations.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pressão Venosa
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Proteína 1 de Ligação a Fator de Crescimento Semelhante à Insulina
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Hepatectomia
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Mucosa Intestinal
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Neoplasias Hepáticas
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article