Human Herpesvirus 8 in Perinatally HIV-infected Children with Interstitial Lung Disease.
J Trop Pediatr
; 64(5): 382-388, 2018 Oct 01.
Article
em En
| MEDLINE
| ID: mdl-29165615
ABSTRACT
INTRODUCTION:
Human herpesvirus 8 (HHV-8) is associated with the pathogenesis of Kaposi Sarcoma and interstitial pneumonitis in adults. This study aims to evaluate association between HHV-8 and interstitial lung disease in HIV-infected children.METHODS:
HIV-infected children with interstitial pneumonitis underwent lung biopsies in a tertiary hospital and were investigated for HHV-8, Epstein-Barr virus (EBV) and cytomegalovirus (CMV) using polymerase chain reaction (PCR) and immunohistochemistry in lung tissue. Peripheral blood PCR was also performed for HHV-8.RESULTS:
From six patients included, PCR for HHV-8 was positive in lung samples in four children and in peripheral blood in one. PCR for EBV and CMV and immunohistochemical study for HHV-8, EBV and CMV in lung were negative in all patients.CONCLUSION:
No previous cases of HHV-8-associated interstitial pneumonitis was described in HIV-infected children. An immunological disorder and an infectious agent might influence development of the lymphoid interstitial pneumonitis. HHV-8 may be this infectious trigger.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Infecções por HIV
/
Doenças Pulmonares Intersticiais
/
Herpesvirus Humano 8
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article