Microtubule-Organizing Centers: Towards a Minimal Parts List.
Trends Cell Biol
; 28(3): 176-187, 2018 03.
Article
em En
| MEDLINE
| ID: mdl-29173799
ABSTRACT
Despite decades of molecular analysis of the centrosome, an important microtubule-organizing center (MTOC) of animal cells, the molecular basis of microtubule organization remains obscure. A major challenge is the sheer complexity of the interplay of the hundreds of proteins that constitute the centrosome. However, this complexity owes not only to the centrosome's role as a MTOC but also to the requirements of its duplication cycle and to various other functions such as the formation of cilia, the integration of various signaling pathways, and the organization of actin filaments. Thus, rather than using the parts lists to reconstruct the centrosome, we propose to identify the subset of proteins minimally needed to assemble a MTOC and to study this process at non-centrosomal sites.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Cílios
/
Centrossomo
/
Centro Organizador dos Microtúbulos
/
Microtúbulos
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article