A High-Throughput Screen for Inhibitors of the Hsp90-Chaperone Machine.
Methods Mol Biol
; 1709: 87-96, 2018.
Article
em En
| MEDLINE
| ID: mdl-29177653
ABSTRACT
Hsp90 has emerged as a key chemotherapeutic target for the development of drugs for the treatment of cancer and neurodegenerative diseases. The shortcomings of many of the Hsp90 inhibitors that have made it to clinical trials have bolstered the need to identify new lead compounds with superior properties. Here, we describe a high-throughput screen for the identification of Hsp90 inhibitors based on the refolding of thermally denatured firefly luciferase.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Proteínas de Choque Térmico HSP90
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Proteômica
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Ensaios de Triagem em Larga Escala
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article