Metal-homeostasis in the pathobiology of the opportunistic human fungal pathogen Aspergillus fumigatus.
Curr Opin Microbiol
; 40: 152-159, 2017 Dec.
Article
em En
| MEDLINE
| ID: mdl-29179120
ABSTRACT
In contrast to obligate pathogens opportunistic pathogens such as Aspergillus fumigatus do not need a specific host to propagate or survive. However several characteristics of the saprophytic life-style and the selective pressure encountered in the primary ecological niche contribute to the virulence of A. fumigatus. All fungi depend on metals for growth and proliferation, like iron, copper, zinc, manganese or calcium. In the recent past several studies explored the manifold impact of metals modulating virulence of pathogens. Components which might be scarce in the natural environment but also in the host due to nutritional immunity. This review recapitulates molecular constituents of metal ion uptake systems in A. fumigatus, their regulation and their significance at the host-pathogen battlefield.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Aspergilose
/
Aspergillus fumigatus
/
Ferro
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article