Capsule Endoscopy Validation of the Magnetic Enterography Global Score in Patients with Established Crohn's Disease.
J Crohns Colitis
; 12(3): 313-320, 2018 Feb 28.
Article
em En
| MEDLINE
| ID: mdl-29182750
ABSTRACT
BACKGROUND AND AIMS:
Capsule endoscopy [CE] and magnetic resonance enterography [MRE] are prime modalities for evaluation of the small bowel in Crohn's disease [CD]. Detection of proximal small bowel [SB] inflammation in CD by MRE is challenging. Currently available quantitative MRE scores do not incorporate proximal SB data. The MRE global score [MEGS] was designed for quantitative evaluation of the entire digestive tract; its accuracy in the proximal SB has not previously been evaluated. This study compared the evaluation of the small bowel inflammation by MEGS and CE-derived quantitative score (the Lewis score[LS]).METHODS:
CD patients in stable clinical remission were prospectively recruited and underwent MRE and CE; faecal calprotectin [FC] levels were obtained. MEGS was calculated for each SB segment and the entire SB [SBMEGS]. SB inflammation on CE was quantified using LS. A cumulative Lewis score [C-LS] was calculated based on summation of three tertiles scores.RESULTS:
Fifty patients were included. There was a significant correlation of SBMEGS with LS and C-LS [r = 0.61 and 0.71, both p = 0.001]. The correlation with FC was stronger for MEGS than for LS or C-LS [r = 0.68 vs r = 0.46 vs r = 0.53, all p = 0.001]. The correlation between the proximal LS and MEGS was significant [r = 0.55, p = 0.001]; median MEGS was significantly different in patients, with LS values consistent with mucosal healing, mild and moderate-to-severe inflammation.CONCLUSIONS:
MEGS provides accurate evaluation of the SB and strongly correlates with FC; the main advantage of MEGS is the accurate quantification of proximal SB inflammation unavailable for alternative MRE scores.
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Base de dados:
MEDLINE
Assunto principal:
Índice de Gravidade de Doença
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Imageamento por Ressonância Magnética
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Doença de Crohn
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Complexo Antígeno L1 Leucocitário
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Endoscopia por Cápsula
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Intestino Delgado
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article