Role of Chromatin assembly factor 1 in DNA replication of Plasmodium falciparum.
Biochem Biophys Res Commun
; 495(1): 1285-1291, 2018 01 01.
Article
em En
| MEDLINE
| ID: mdl-29183721
ABSTRACT
Nucleosome assembly in P. falciparum could be the key process in maintaining its genomic integrity as DNA replicates more than once per cell cycle during several stages of its life cycle. Here, we report the functional characterization of P. falciparum chromatin assembly factor 1 (CAF1), which interacts with several proteins namely PfCAF2, Histones, PfHP1 and others. Consistent with the above findings, we demonstrate the presence of PfCAF1 at the telomeric repeat regions, central and subtelomeric var genes of multiple var gene family along with PfHP1. Further, we report the upregulation of PfCAF1 after treatment with genotoxic agents like MMS and HU. Together, these findings establish role of PfCAF1 in heterochromatin maintenance and as histone chaperone in nucleosome assembly and DNA damage repair.
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Base de dados:
MEDLINE
Assunto principal:
Plasmodium falciparum
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Nucleossomos
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DNA de Protozoário
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Reparo do DNA
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Replicação do DNA
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Fator 1 de Modelagem da Cromatina
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article