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DKK3 overexpression attenuates cardiac hypertrophy and fibrosis in an angiotensin-perfused animal model by regulating the ADAM17/ACE2 and GSK-3ß/ß-catenin pathways.
Zhai, Chun-Gang; Xu, Ye-Yang; Tie, Yuan-Yuan; Zhang, Ya; Chen, Wen-Qiang; Ji, Xiao-Ping; Mao, Yang; Qiao, Lei; Cheng, Jing; Xu, Qing-Bo; Zhang, Cheng.
Afiliação
  • Zhai CG; Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese Ministry of Health, Qilu Hospital of Shandong University, Jinan, Shandong, China.
  • Xu YY; Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese Ministry of Health, Qilu Hospital of Shandong University, Jinan, Shandong, China.
  • Tie YY; Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese Ministry of Health, Qilu Hospital of Shandong University, Jinan, Shandong, China.
  • Zhang Y; Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese Ministry of Health, Qilu Hospital of Shandong University, Jinan, Shandong, China.
  • Chen WQ; Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese Ministry of Health, Qilu Hospital of Shandong University, Jinan, Shandong, China.
  • Ji XP; Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese Ministry of Health, Qilu Hospital of Shandong University, Jinan, Shandong, China.
  • Mao Y; Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese Ministry of Health, Qilu Hospital of Shandong University, Jinan, Shandong, China.
  • Qiao L; Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese Ministry of Health, Qilu Hospital of Shandong University, Jinan, Shandong, China.
  • Cheng J; Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese Ministry of Health, Qilu Hospital of Shandong University, Jinan, Shandong, China.
  • Xu QB; Cardiovascular Division, King's College London, BHF Centre, London, UK.
  • Zhang C; Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese Ministry of Health, Qilu Hospital of Shandong University, Jinan, Shandong, China. Electronic address: zhangc@sdu.edu.cn.
J Mol Cell Cardiol ; 114: 243-252, 2018 01.
Article em En | MEDLINE | ID: mdl-29196099
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Angiotensina II / Transdução de Sinais / Cardiomegalia / Peptídeos e Proteínas de Sinalização Intercelular / Beta Catenina / Glicogênio Sintase Quinase 3 beta / Proteína ADAM17 Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Angiotensina II / Transdução de Sinais / Cardiomegalia / Peptídeos e Proteínas de Sinalização Intercelular / Beta Catenina / Glicogênio Sintase Quinase 3 beta / Proteína ADAM17 Idioma: En Ano de publicação: 2018 Tipo de documento: Article