Neuropeptides and ATP signaling in the trigeminal ganglion.
Jpn Dent Sci Rev
; 53(4): 117-124, 2017 Nov.
Article
em En
| MEDLINE
| ID: mdl-29201256
ABSTRACT
Peripheral nociceptive stimuli from orofacial structures are largely transmitted by the trigeminal nerve. According to the peripheral noxious stimuli, neurons in the trigeminal ganglion (TG) produce neuropeptides such as substance P, and calcitonin-gene-related peptide, etc. Beside the production of neuropeptides, there exists unique non-synaptic interaction system between maxillary and mandibular neurons in the TG. Neurons in the TG are surrounded by satellite glial cells (SGCs), which initially receive the signal from TG neurons. These activated SGCs secrete a transmitter to activate adjacent SGCs or TG neurons, thereby amplifying the signal, for example, from mandibular neurons to maxillary neurons in the TG. Similar to the dorsal root ganglion, in the TG, microglia/macrophage-like cells (MLCs) are activated by uptake of a transmitter from TG neurons or SGCs. This communication between neurons, SGCs, and MLCs results in responses such as ectopic pain, hyperesthesia, or allodynia. The focus of this review is the cooperative interaction of the maxillary and mandibular nerves in the TG by neuropeptides, and adenosine 3'-phosphate (ATP) signaling from neurons to SGCs and MLCs. Stimulated neurons either secrete ATP by means of vesicular nucleotide transporters, or secrete neuropeptides from the neuronal cell body to mediate signal transmission.
ATP; ATP, adenosine 3'-phosphate; CGRP, calcitonin-gene-related peptide; DRG, dorsal root ganglion; MLC, microglia/macrophage-like cell; Neuron; Neuropeptides; PACAP, pituitary adenylate-cyclase-activating polypeptide receptor type 1; SGC, satellite glial cell; SP, substance P; Satellite glial cell; TG, trigeminal ganglion; Trigeminal ganglion; VIP, vasoactive intestinal peptide; VNUT, vesicular nucleotide transporter
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MEDLINE
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En
Ano de publicação:
2017
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Article