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When Cancer Cells Are Given Lemo[NH3]s, They Make Lemo[NH3]ade.
Shan, Mengrou; Lyssiotis, Costas A.
Afiliação
  • Shan M; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.
  • Lyssiotis CA; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA; Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: clyssiot@med.umich.edu.
Cell Metab ; 26(6): 811-813, 2017 12 05.
Article em En | MEDLINE | ID: mdl-29211980
In normal physiology, end-products of metabolism are excreted from the body. In tumors, these metabolic wastes accumulate due to deregulated metabolism and vascular insufficiency. Spinelli et al. (2017) show that breast cancer cells adapt to ammonia buildup by recycling it for amino acid synthesis, which can support cancer cell growth.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Amônia Idioma: En Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Amônia Idioma: En Ano de publicação: 2017 Tipo de documento: Article