Protein tyrosine phosphatase 1B inhibitors from natural sources.
Arch Pharm Res
; 41(2): 130-161, 2018 Feb.
Article
em En
| MEDLINE
| ID: mdl-29214599
ABSTRACT
Since PTP1B enzyme was discovered in 1988, it has captured the research community's attention. This landmark discovery has stimulated numerous research studies on a variety of human diseases, including cancer, inflammation, and diabetes. Tremendous progress has been made in finding PTP1B inhibitors and exploring PTP1B regulatory mechanisms. This review investigates for the natural PTP1B inhibitors, and focuses on the common characteristics of the discovered structures and structure-activity relationships. To facilitate understanding, all the natural compounds are here divided into five different classes (fatty acids, phenolics, terpenoids, steroids, and alkaloids), according to their skeletons. These PTP1B inhibitors of scaffold structures could serve as a theoretical basis for new concept drug discovery and design.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Produtos Biológicos
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Proteína Tirosina Fosfatase não Receptora Tipo 1
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article