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Measuring mutation accumulation in single human adult stem cells by whole-genome sequencing of organoid cultures.
Jager, Myrthe; Blokzijl, Francis; Sasselli, Valentina; Boymans, Sander; Janssen, Roel; Besselink, Nicolle; Clevers, Hans; van Boxtel, Ruben; Cuppen, Edwin.
Afiliação
  • Jager M; Center for Molecular Medicine and Oncode Institute, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
  • Blokzijl F; Center for Molecular Medicine and Oncode Institute, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
  • Sasselli V; Hubrecht Institute for Developmental Biology and Stem Cell Research, KNAW and University Medical Center Utrecht, Utrecht, the Netherlands.
  • Boymans S; Center for Molecular Medicine and Oncode Institute, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
  • Janssen R; Center for Molecular Medicine and Oncode Institute, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
  • Besselink N; Center for Molecular Medicine and Oncode Institute, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
  • Clevers H; Hubrecht Institute for Developmental Biology and Stem Cell Research, KNAW and University Medical Center Utrecht, Utrecht, the Netherlands.
  • van Boxtel R; Center for Molecular Medicine and Oncode Institute, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
  • Cuppen E; Center for Molecular Medicine and Oncode Institute, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
Nat Protoc ; 13(1): 59-78, 2018 Jan.
Article em En | MEDLINE | ID: mdl-29215633
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Organoides / Células-Tronco Adultas / Acúmulo de Mutações / Sequenciamento Completo do Genoma / Mutação Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Organoides / Células-Tronco Adultas / Acúmulo de Mutações / Sequenciamento Completo do Genoma / Mutação Idioma: En Ano de publicação: 2018 Tipo de documento: Article