In-vitro and In-vivo Pharmacokinetic Evaluation of Guar Gum-Eudragit&#174; S100 Based Colon-targeted Spheroids of Sulfasalazine Co-administered with Probiotics.

Sharma, Abhinav; Kumar, Bimlesh; Singh, Sachin Kumar; Gulati, Monica; Vaidya, Yogyata; Rathee, Harish; Ghai, Deepak; Malik, Adil Hussain; Yadav, Ankit Kumar; Maharshi, Peddi; Bawa, Palak; Rajesh, Sarvi Yadav; Sharma, Parth; Pandey, Narendra Kumar; Mohanta, Souvik

In-vitro and In-vivo Pharmacokinetic Evaluation of Guar Gum-Eudragit® S100 Based Colon-targeted Spheroids of Sulfasalazine Co-administered with Probiotics.

Sharma, Abhinav; Kumar, Bimlesh; Singh, Sachin Kumar; Gulati, Monica; Vaidya, Yogyata; Rathee, Harish; Ghai, Deepak; Malik, Adil Hussain; Yadav, Ankit Kumar; Maharshi, Peddi; Bawa, Palak; Rajesh, Sarvi Yadav; Sharma, Parth; Pandey, Narendra Kumar; Mohanta, Souvik.

Afiliação

Sharma A; School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab-144 411, India.
Kumar B; School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab-144 411, India.
Singh SK; School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab-144 411, India.
Gulati M; School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab-144 411, India.
Vaidya Y; School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab-144 411, India.
Rathee H; School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab-144 411, India.
Ghai D; School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab-144 411, India.
Malik AH; School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab-144 411, India.
Yadav AK; School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab-144 411, India.
Maharshi P; School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab-144 411, India.
Bawa P; School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab-144 411, India.
Rajesh SY; School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab-144 411, India.
Sharma P; School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab-144 411, India.
Pandey NK; School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab-144 411, India.
Mohanta S; School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab-144 411, India.

Curr Drug Deliv ; 15(3): 367-387, 2018.

Article em En | MEDLINE | ID: mdl-29219056

Assuntos

Colo/metabolismo; Sistemas de Liberação de Medicamentos; Galactanos/administração & dosagem; Fármacos Gastrointestinais/administração & dosagem; Mananas/administração & dosagem; Gomas Vegetais/administração & dosagem; Ácidos Polimetacrílicos/administração & dosagem; Probióticos/administração & dosagem; Sulfassalazina/administração & dosagem; Animais; Preparações de Ação Retardada/administração & dosagem; Preparações de Ação Retardada/química; Preparações de Ação Retardada/farmacocinética; Feminino; Galactanos/química; Galactanos/farmacocinética; Fármacos Gastrointestinais/química; Fármacos Gastrointestinais/farmacocinética; Masculino; Mananas/química; Mananas/farmacocinética; Gomas Vegetais/química; Gomas Vegetais/farmacocinética; Ácidos Polimetacrílicos/química; Ácidos Polimetacrílicos/farmacocinética; Probióticos/química; Probióticos/farmacocinética; Ratos Sprague-Dawley; Sulfassalazina/química; Sulfassalazina/farmacocinética

Palavras-chave

Sulfasalazine; delayed release tablets; dissolution; pharmacokinetics; probiotics; spheroids

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ácidos Polimetacrílicos / Sulfassalazina / Fármacos Gastrointestinais / Sistemas de Liberação de Medicamentos / Colo / Probióticos / Gomas Vegetais / Galactanos / Mananas Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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