Diagnostic and prognostic tests in systemic lupus erythematosus.
Best Pract Res Clin Rheumatol
; 31(3): 351-363, 2017 06.
Article
em En
| MEDLINE
| ID: mdl-29224677
ABSTRACT
Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disease characterized by autoantibodies directed against numerous self-nuclear antigens. Because of the heterogeneous nature of lupus, it has been challenging to identify markers that are sensitive and specific enough for its diagnosis and monitoring. However, with the sequencing of the human genome, rapid development of high-throughput approaches has allowed for a better understanding of the etiopathogenesis of complex diseases, including SLE. Here we present a review of the latest advancements in biomarker discovery during the "omics" era, using these novel technologies, for assisting in the diagnosis and prognosis of patients with SLE.
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Base de dados:
MEDLINE
Assunto principal:
Proteômica
/
Lúpus Eritematoso Sistêmico
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article