A Randomized Controlled Multicenter Trial of an Investigational Liquid Nutritional Formula in Women with Cyclic Breast Pain Associated with Fibrocystic Breast Changes.
J Womens Health (Larchmt)
; 27(3): 333-340, 2018 03.
Article
em En
| MEDLINE
| ID: mdl-29237134
ABSTRACT
OBJECTIVE:
A randomized, multicenter, controlled double-blind trial was performed in women with cyclic breast pain (mastalgia) associated with fibrocystic breast changes (FBCs) to determine whether a nutritional formula reduced breast pain and/or nodularity. STUDYDESIGN:
Women were randomized to receive a specifically designed liquid formulation (n = 93) (1 g gamma-linolenic acid [GLA], 750 µg iodine, and 70 µg selenium) or control formula (n = 95) (without GLA, iodine, and selenium) daily for three cycles. Women recorded breast pain, medications, and menstrual signs daily using interactive voice-response system. Nodularity was determined by physical breast examination.RESULTS:
Breast pain scores decreased similarly in the experimental (-32.2%) and control (-33.1%) groups (p = 0.64). Nodularity was reduced in the experimental, but not the control group (p = 0.03). Among women who continued pain medication, the amount was reduced in the experimental group relative to controls (p = 0.02).CONCLUSION:
Women with FBC using the formula containing GLA, iodine, and selenium experienced reduced nodularity and in those women who took over-the-counter breast pain medication, a decrease in the quantity of pain medication was observed.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Dor
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Selênio
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Mama
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Doenças Mamárias
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Ácido gama-Linolênico
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Mastodinia
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Iodo
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Ciclo Menstrual
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article