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Structure-activity studies on N-Substituted tranylcypromine derivatives lead to selective inhibitors of lysine specific demethylase 1 (LSD1) and potent inducers of leukemic cell differentiation.
Schulz-Fincke, Johannes; Hau, Mirjam; Barth, Jessica; Robaa, Dina; Willmann, Dominica; Kürner, Andreas; Haas, Julian; Greve, Gabriele; Haydn, Tinka; Fulda, Simone; Lübbert, Michael; Lüdeke, Steffen; Berg, Tobias; Sippl, Wolfgang; Schüle, Roland; Jung, Manfred.
Afiliação
  • Schulz-Fincke J; Institute of Pharmaceutical Sciences, University of Freiburg, Germany; German Cancer Consortium (DKTK), Freiburg, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Hau M; Institute of Pharmaceutical Sciences, University of Freiburg, Germany.
  • Barth J; German Cancer Consortium (DKTK), Frankfurt, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Robaa D; Institute of Pharmacy, Martin-Luther-University of Halle-Wittenberg, Germany.
  • Willmann D; Department of Urology and Center for Clinical Research, University of Freiburg Medical Center, Germany.
  • Kürner A; Institute of Pharmaceutical Sciences, University of Freiburg, Germany; German Cancer Consortium (DKTK), Freiburg, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Haas J; Institute of Pharmaceutical Sciences, University of Freiburg, Germany.
  • Greve G; Division of Hematology, Oncology and Stem Cell Transplantation, Department of Internal Medicine, University of Freiburg Medical Center, Germany; Faculty of Biology, University of Freiburg, Germany.
  • Haydn T; Institute for Experimental Cancer Research in Pediatrics, Goethe-University Frankfurt, Germany; German Cancer Consortium (DKTK), Frankfurt, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Fulda S; Institute for Experimental Cancer Research in Pediatrics, Goethe-University Frankfurt, Germany; German Cancer Consortium (DKTK), Frankfurt, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Lübbert M; Division of Hematology, Oncology and Stem Cell Transplantation, Department of Internal Medicine, University of Freiburg Medical Center, Germany; German Cancer Consortium (DKTK), Freiburg, Germany.
  • Lüdeke S; Institute of Pharmaceutical Sciences, University of Freiburg, Germany.
  • Berg T; German Cancer Consortium (DKTK), Frankfurt, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Sippl W; Institute of Pharmacy, Martin-Luther-University of Halle-Wittenberg, Germany.
  • Schüle R; German Cancer Consortium (DKTK), Freiburg, Germany; Department of Urology and Center for Clinical Research, University of Freiburg Medical Center, Germany; BIOSS Centre of Biological Signalling Studies, University of Freiburg, Freiburg, Germany; K-metics GmbH, Freiburg, Germany.
  • Jung M; Institute of Pharmaceutical Sciences, University of Freiburg, Germany; K-metics GmbH, Freiburg, Germany. Electronic address: manfred.jung@pharmazie.uni-freiburg.de.
Eur J Med Chem ; 144: 52-67, 2018 Jan 20.
Article em En | MEDLINE | ID: mdl-29247860
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tranilcipromina / Inibidores Enzimáticos / Histona Desmetilases Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tranilcipromina / Inibidores Enzimáticos / Histona Desmetilases Idioma: En Ano de publicação: 2018 Tipo de documento: Article