5-FU resistant EMT-like pancreatic cancer cells are hypersensitive to photochemical internalization of the novel endoglin-targeting immunotoxin CD105-saporin.

Lund, Kaja; Olsen, Cathrine Elisabeth; Wong, Judith Jing Wen; Olsen, Petter Angell; Solberg, Nina Therese; Høgset, Anders; Krauss, Stefan; Selbo, Pål Kristian

Lund, Kaja; Olsen, Cathrine Elisabeth; Wong, Judith Jing Wen; Olsen, Petter Angell; Solberg, Nina Therese; Høgset, Anders; Krauss, Stefan; Selbo, Pål Kristian.

Afiliação

Lund K; Unit for Cell Signaling, Institute of Microbiology, Rikshospitalet, 0372, Oslo, Norway. Kaja.Lund@rr-research.no.
Olsen CE; Hybrid Technology Hub - Centre of Excellence, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, PO Box 1112, Blindern, 0317, Oslo, Norway. Kaja.Lund@rr-research.no.
Wong JJW; Department of Radiation Biology, Institute for Cancer Research, Norwegian Radium Hospital, Oslo University Hospital, 0379, Oslo, Norway.
Olsen PA; Department of Radiation Biology, Institute for Cancer Research, Norwegian Radium Hospital, Oslo University Hospital, 0379, Oslo, Norway.
Solberg NT; Unit for Cell Signaling, Institute of Microbiology, Rikshospitalet, 0372, Oslo, Norway.
Høgset A; Hybrid Technology Hub - Centre of Excellence, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, PO Box 1112, Blindern, 0317, Oslo, Norway.
Krauss S; Unit for Cell Signaling, Institute of Microbiology, Rikshospitalet, 0372, Oslo, Norway.
Selbo PK; Hybrid Technology Hub - Centre of Excellence, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, PO Box 1112, Blindern, 0317, Oslo, Norway.

J Exp Clin Cancer Res ; 36(1): 187, 2017 Dec 19.

Article em En | MEDLINE | ID: mdl-29258566

Assuntos

Adenocarcinoma/patologia; Imunotoxinas/farmacologia; Neoplasias Pancreáticas/patologia; Fármacos Fotossensibilizantes/farmacologia; Porfirinas/farmacologia; Antineoplásicos; Autofagia/efeitos dos fármacos; Linhagem Celular Tumoral; Resistencia a Medicamentos Antineoplásicos/efeitos dos fármacos; Endoglina/antagonistas & inibidores; Transição Epitelial-Mesenquimal; Fluoruracila; Humanos; Fototerapia/métodos; Proteínas Inativadoras de Ribossomos Tipo 1/farmacologia; Saporinas

Palavras-chave

5-FU resistance; Autophagy; CD105; Endoglin; Pancreatic cancer; Photochemical internalization

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Porfirinas / Adenocarcinoma / Imunotoxinas / Fármacos Fotossensibilizantes Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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