Siglec-1 inhibits RSV-induced interferon gamma production by adult T cells in contrast to newborn T cells.
Eur J Immunol
; 48(4): 621-631, 2018 04.
Article
em En
| MEDLINE
| ID: mdl-29266251
ABSTRACT
Interferon gamma (IFN-γ) plays an important role in the antiviral immune response during respiratory syncytial virus (RSV) infections. Monocytes and T cells are recruited to the site of RSV infection, but it is unclear whether cell-cell interactions between monocytes and T cells regulate IFN-γ production. In this study, micro-array data identified the upregulation of sialic acid-binding immunoglobulin-type lectin 1 (Siglec-1) in human RSV-infected infants. In vitro, RSV increased expression of Siglec-1 on healthy newborn and adult monocytes. RSV-induced Siglec-1 on monocytes inhibited IFN-γ production by adult CD4+ T cells. In contrast, IFN-γ production by RSV in newborns was not affected by Siglec-1. The ligand for Siglec-1, CD43, is highly expressed on adult CD4+ T cells compared to newborns. Our data show that Siglec-1 reduces IFN-γ release by adult T cells possibly by binding to the highly expressed CD43. The Siglec-1-dependent inhibition of IFN-γ in adults and the low expression of CD43 on newborn T cells provides a better understanding of the immune response against RSV in early life and adulthood.
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Base de dados:
MEDLINE
Assunto principal:
Monócitos
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Linfócitos T CD4-Positivos
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Interferon gama
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Vírus Sincicial Respiratório Humano
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Infecções por Vírus Respiratório Sincicial
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Lectina 1 Semelhante a Ig de Ligação ao Ácido Siálico
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article