Combination treatment of celecoxib and ciprofloxacin attenuates live S. aureus induced oxidative damage and inflammation in murine microglia via regulation of cytokine balance.
J Neuroimmunol
; 316: 23-39, 2018 03 15.
Article
em En
| MEDLINE
| ID: mdl-29269130
ABSTRACT
Microglial activation is the most common phenomenon in S. aureus induced brain abscesses as well as other common neurodegenerative diseases. The main objective of this study is to reduce the microglial inflammation with effective bacterial elimination. Ciprofloxacin and celecoxib were used in combination to regulate S. aureus induced oxidative stress and inflammation in primary murine microglial cells. Our results showed that combination treatment effectively killed viable S. aureus and reduced the inflammatory consequences. It can be concluded that lower production of pro-inflammatory cytokines and higher anti-inflammatory IL-10 level may be responsible for microglial polarization switching from pro-inflammatory M1 to anti-inflammatory M2.
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Base de dados:
MEDLINE
Assunto principal:
Ciprofloxacina
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Citocinas
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Microglia
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Estresse Oxidativo
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Celecoxib
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article