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α-glucosidase inhibitors isolated from Mimosa pudica L.
Tasnuva, S T; Qamar, U A; Ghafoor, Kashif; Sahena, F; Jahurul, M H A; Rukshana, A H; Juliana, M J; Al-Juhaimi, Fahad Y; Jalifah, L; Jalal, K C A; Ali, Md Eaqub; Zaidul, I S M.
Afiliação
  • Tasnuva ST; a Faculty of Pharmacy , International Islamic University Malaysia, Kuantan Campus , Kuantan , Malaysia.
  • Qamar UA; a Faculty of Pharmacy , International Islamic University Malaysia, Kuantan Campus , Kuantan , Malaysia.
  • Ghafoor K; b Department of Food Science and Nutrition , King Saud University , Riyadh , Saudi Arabia.
  • Sahena F; c Faculty of Science , International Islamic University Malaysia (IIUM), Kuantan Campus , Kuantan , Malaysia.
  • Jahurul MHA; d Faculty of Food Science and Nutrition , Universiti Malaysia Sabah , Kota Kinabalu , Malaysia.
  • Rukshana AH; e Faculty of Basic Medical and Pharmaceutical Sciences , University of Science and Technology Chittagong , Chittagong , Bangladesh.
  • Juliana MJ; a Faculty of Pharmacy , International Islamic University Malaysia, Kuantan Campus , Kuantan , Malaysia.
  • Al-Juhaimi FY; b Department of Food Science and Nutrition , King Saud University , Riyadh , Saudi Arabia.
  • Jalifah L; f Faculty of Science and Technology , University Kebangsaan Malaysia , Bangi , Malaysia.
  • Jalal KCA; c Faculty of Science , International Islamic University Malaysia (IIUM), Kuantan Campus , Kuantan , Malaysia.
  • Ali ME; g Nanotechnology and Catalysis Research Centre (NanoCat) , University of Malaya , Kuala Lumpur , Malaysia.
  • Zaidul ISM; a Faculty of Pharmacy , International Islamic University Malaysia, Kuantan Campus , Kuantan , Malaysia.
Nat Prod Res ; 33(10): 1495-1499, 2019 May.
Article em En | MEDLINE | ID: mdl-29281898
The aim of the study was to isolate digestive enzymes inhibitors from Mimosa pudica through a bioassay-guided fractionation approach. Repeated silica gel and sephadex LH 20 column chromatographies of bioactive fractions afforded stigmasterol, quercetin and avicularin as digestive enzymes inhibitors whose IC50 values as compared to acarbose (351.02 ± 1.46 µg mL-1) were found to be as 91.08 ± 1.54, 75.16 ± 0.92 and 481.7 ± 0.703 µg mL-1, respectively. In conclusion, M. pudica could be a good and safe source of digestive enzymes inhibitors for the management of diabetes in future.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Mimosa / Inibidores de Glicosídeo Hidrolases Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Mimosa / Inibidores de Glicosídeo Hidrolases Idioma: En Ano de publicação: 2019 Tipo de documento: Article