Pneumonia diagnosis in childhood and incidence of leukaemia, lymphoma and brain cancer: a Danish nationwide cohort study.
BMJ Open
; 7(12): e019860, 2017 12 29.
Article
em En
| MEDLINE
| ID: mdl-29289943
ABSTRACT
OBJECTIVES:
There is an ongoing debate on the possible association between infections in early childhood and subsequent cancer risk, but it remains unclear if a hospital admission for infection is associated with risk of childhood cancer diagnosis. We examined if a hospital-based diagnosis of pneumonia was a clinical marker of the three most common childhood cancers.DESIGN:
Population-based cohort study.SETTING:
Denmark, hospital diagnoses, 1994-2013.METHODS:
Using national health registries, we compared the observed incidence of leukaemia, lymphoma and brain cancer among 83 935 children with a hospital-based pneumonia diagnosis with that expected among children in the general population. We calculated absolute cancer risks and standardised incidence ratios (SIRs) as a measure of relative risk.RESULTS:
The cancer SIRs were substantially increased during the first 6 months of follow-up; lymphoid leukaemia 6.2 (95% CI 3.5 to 10.3); myeloid leukaemia 14.8 (95% CI 6.0 to 30.6); Hodgkin's lymphoma 60.8 (95% CI 26.2 to 120), non-Hodgkin's lymphoma 15.9 (95% CI 5.2 to 37.2) and brain cancer 4.4 (95% CI 1.9 to 8.7). The 6-month absolute risks of leukaemia, lymphoma and brain cancer were all low, reaching 0.05% when combined. An increased risk persisted beyond 5 years for non-Hodgkin's lymphoma and brain cancer. However, the 5-year absolute cancer risk was 0.14%.CONCLUSIONS:
The short-term incidence of leukaemia, lymphoma and brain cancer was higher than expected and persisted beyond 5 years for non-Hodgkin's lymphoma and brain cancer. However, the absolute cancer risk was low.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Pneumonia
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Neoplasias Encefálicas
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Leucemia
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Linfoma
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article