The Role of Heparan Sulfate in Inflammation, and the Development of Biomimetics as Anti-Inflammatory Strategies.
J Histochem Cytochem
; 66(4): 321-336, 2018 04.
Article
em En
| MEDLINE
| ID: mdl-29290153
ABSTRACT
Key events that occur during inflammation include the recruitment, adhesion, and transmigration of leukocytes from the circulation to the site of inflammation. These events are modulated by chemokines, integrins, and selectins and the interaction of these molecules with glycosaminoglycans, predominantly heparan sulfate (HS). The development of HS/heparin mimetics that interfere or inhibit the interactions that occur between glycosaminoglycans and modulators of inflammation holds great potential for use as anti-inflammatory therapeutics. This review will detail the role of HS in the events that occur during inflammation, their interaction and modulation of inflammatory mediators, and the current advances in the development of HS/heparin mimetics as anti-inflammatory biotherapeutics.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Descoberta de Drogas
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Heparitina Sulfato
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Imunidade Inata
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Inflamação
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Anti-Inflamatórios
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article