Circulating exosomes suppress the induction of regulatory T cells via let-7i in multiple sclerosis.

Kimura, Kimitoshi; Hohjoh, Hirohiko; Fukuoka, Masashi; Sato, Wakiro; Oki, Shinji; Tomi, Chiharu; Yamaguchi, Hiromi; Kondo, Takayuki; Takahashi, Ryosuke; Yamamura, Takashi

Kimura, Kimitoshi; Hohjoh, Hirohiko; Fukuoka, Masashi; Sato, Wakiro; Oki, Shinji; Tomi, Chiharu; Yamaguchi, Hiromi; Kondo, Takayuki; Takahashi, Ryosuke; Yamamura, Takashi.

Afiliação

Kimura K; Department of Immunology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi, Kodaira, Tokyo, 187-8502, Japan.
Hohjoh H; Department of Neurology, Kyoto University Graduate School of Medicine, Yoshida-konoe-cho, Sakyo, Kyoto, 606-8501, Japan.
Fukuoka M; Department of Molecular Pharmacology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi, Kodaira, Tokyo, 187-8502, Japan.
Sato W; Department of Molecular Pharmacology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi, Kodaira, Tokyo, 187-8502, Japan.
Oki S; Department of Immunology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi, Kodaira, Tokyo, 187-8502, Japan.
Tomi C; Multiple Sclerosis Center, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi, Kodaira, Tokyo, 187-8551, Japan.
Yamaguchi H; Department of Immunology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi, Kodaira, Tokyo, 187-8502, Japan.
Kondo T; Department of Immunology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi, Kodaira, Tokyo, 187-8502, Japan.
Takahashi R; Department of Immunology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi, Kodaira, Tokyo, 187-8502, Japan.
Yamamura T; Department of Neurology, Kyoto University Graduate School of Medicine, Yoshida-konoe-cho, Sakyo, Kyoto, 606-8501, Japan.

Nat Commun ; 9(1): 17, 2018 01 02.

Article em En | MEDLINE | ID: mdl-29295981

Assuntos

Exossomos/imunologia; MicroRNAs/imunologia; Esclerose Múltipla/imunologia; Linfócitos T Reguladores/imunologia; Adulto; Linfócitos T CD4-Positivos/imunologia; Linfócitos T CD4-Positivos/metabolismo; Exossomos/genética; Exossomos/metabolismo; Feminino; Fatores de Transcrição Forkhead/genética; Fatores de Transcrição Forkhead/imunologia; Fatores de Transcrição Forkhead/metabolismo; Humanos; Interleucina-17/genética; Interleucina-17/imunologia; Interleucina-17/metabolismo; Masculino; MicroRNAs/genética; Pessoa de Meia-Idade; Esclerose Múltipla/sangue; Esclerose Múltipla/genética; Proteínas Serina-Treonina Quinases/genética; Proteínas Serina-Treonina Quinases/imunologia; Proteínas Serina-Treonina Quinases/metabolismo; Receptor IGF Tipo 1; Receptor do Fator de Crescimento Transformador beta Tipo I; Receptores de Somatomedina/genética; Receptores de Somatomedina/imunologia; Receptores de Somatomedina/metabolismo; Receptores de Fatores de Crescimento Transformadores beta/genética; Receptores de Fatores de Crescimento Transformadores beta/imunologia; Receptores de Fatores de Crescimento Transformadores beta/metabolismo; Linfócitos T Reguladores/metabolismo; Transcriptoma/imunologia

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Linfócitos T Reguladores / MicroRNAs / Exossomos / Esclerose Múltipla Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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