Oxidatively Generated Lesions as Internal Photosensitizers for Pyrimidine Dimerization in DNA.
ACS Chem Biol
; 13(3): 542-547, 2018 03 16.
Article
em En
| MEDLINE
| ID: mdl-29300457
ABSTRACT
In this work, the attention is focused on UVA-photosensitized reactions triggered by a DNA chromophore-containing lesion, namely 5-formyluracil. This is a major oxidatively generated lesion that exhibits an enhanced light absorption in the UVB-UVA region. The mechanistic study combining photochemical and photobiological techniques shows that irradiation of 5-formyluracil leads to a triplet excited state capable of sensitizing formation of cyclobutane pyrimidine dimers in DNA via a triplet-triplet energy transfer. This demonstrates for the first time that oxidatively generated DNA damage can behave as an intrinsic sensitizer and result in an important extension of the active fraction of the solar spectrum with photocarcinogenic potential. Overall, this raises the question of an aggravated photomutagenicity of the 5-formyluracil lesion.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Dímeros de Pirimidina
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DNA
/
Fármacos Fotossensibilizantes
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article