MicroRNA-187 Inhibits Growth and Metastasis of Osteosarcoma by Downregulating S100A4.
Cancer Invest
; 36(1): 1-9, 2018 Jan 02.
Article
em En
| MEDLINE
| ID: mdl-29303365
ABSTRACT
Abnormal expression and dysfunction of microRNAs are correlated with osteosarcoma (OS). This study demonstrated that the miR-187 level in OS tissues and cell lines was decreased. The proliferation and metastatic abilities of U-2OS cells were inhibited by miR-187 overexpression and promoted by miR-187 knockdown. Moreover, miR-187 also inhibited growth and metastasis of OS cells in vivo. Furthermore, we revealed that miR-187 could interact with S100A4 3'-UTR and inhibit S100A4 expression in OS cells. In summary, miR-187 inhibits growth and metastasis of OS cells by downregulating S100A4, which might be a potential biomarker and therapeutic target of OS.
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Assunto principal:
Neoplasias Ósseas
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Osteossarcoma
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Regulação para Baixo
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MicroRNAs
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Proliferação de Células
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Proteína A4 de Ligação a Cálcio da Família S100
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Metástase Neoplásica
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article