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Bioavailable serum estradiol may alter radiation risk of postmenopausal breast cancer: a nested case-control study.
Grant, Eric J; Cologne, John B; Sharp, Gerald B; Eguchi, Hidetaka; Stevens, Richard G; Izumi, Shizue; Kim, Young-Min; Berrington de González, Amy; Ohishi, Waka; Nakachi, Kei.
Afiliação
  • Grant EJ; a Radiation Effects Research Foundation , Hiroshima , Japan.
  • Cologne JB; b Department of Statistics , Radiation Effects Research Foundation , Hiroshima , Japan.
  • Sharp GB; c Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Epidemiology Branch, Basic Sciences Program , Bethesda , MD , USA.
  • Eguchi H; d Translational Research Division , Research Center for Genomic Medicine, Saitama Medical University , Saitama , Japan.
  • Stevens RG; e Department of Community Medicine , University of Connecticut Health Center , Farmington, CT , USA.
  • Izumi S; f Center for Data Science Education and Research, Shiga University , Hikone , Japan.
  • Kim YM; g Department of Statistics, College of Natural Science , Kyungpook National University , Daegu , South Korea.
  • Berrington de González A; h Division of Cancer Epidemiology and Genetics , NCI/NIH , Bethesda , MD , USA.
  • Ohishi W; i Department of Clinical Studies , Radiation Effects Research Foundation , Hiroshima , Japan.
  • Nakachi K; j Department of Molecular Biosciences , Radiation Effects Research Foundation , Hiroshima , Japan.
Int J Radiat Biol ; 94(2): 97-105, 2018 02.
Article em En | MEDLINE | ID: mdl-29307255
ABSTRACT

PURPOSE:

Ionizing radiation and high levels of circulating estradiol are known breast cancer carcinogens. We investigated the risk of first primary postmenopausal breast cancer in relation to the combined effects of whole-body ionizing radiation exposure and prediagnostic levels of postmenopausal sex hormones, particularly bioavailable estradiol (bE2). MATERIALS AND

METHODS:

A nested case-control study of 57 incident breast cancer cases matched with 110 controls among atomic bomb survivors. Joint effects of breast radiation dose and circulating levels of sex hormones were assessed using binary regression and path analysis. RESULTS AND

CONCLUSION:

Radiation exposure, higher levels of bE2, testosterone and progesterone, and established reproductive risk factors were positively associated with postmenopausal breast cancer risk. A test for mediation of the effect of radiation via bE2 level suggested a small (14%) but significant mediation (p = 0.004). The estimated interaction between radiation and bE2 was large but not significant (interaction = 3.86; p = 0.32). There is accumulating evidence that ionizing radiation not only damages DNA but also alters other organ systems. While caution is needed, some portion of the radiation risk of postmenopausal breast cancer appeared to be mediated through bE2 levels, which may be evidence for cancer risks due to both direct and indirect effects of radiation.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Estradiol / Neoplasias Induzidas por Radiação Idioma: En Ano de publicação: 2018 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Estradiol / Neoplasias Induzidas por Radiação Idioma: En Ano de publicação: 2018 Tipo de documento: Article