Distinct and heterogeneous trajectories of self-perceived cognitive impairment among Asian breast cancer survivors.
Psychooncology
; 27(4): 1185-1192, 2018 04.
Article
em En
| MEDLINE
| ID: mdl-29315963
ABSTRACT
OBJECTIVES:
Currently, there are no studies that have established the self-perceived cognitive trajectories experienced by breast cancer patients (BCPs) post-chemotherapy. Therefore, we characterized the long-term trajectory of self-perceived cognitive function among Asian early-stage BCPs using the minimal clinically important difference of a subjective measure of cognitive function.METHODS:
Early-stage BCPs who received chemotherapy were recruited and assessed at 4 time points Before chemotherapy initiation (T1), 6 weeks post-chemotherapy initiation (T2), 12 weeks post-chemotherapy initiation (T3), and 15-months post-chemotherapy initiation (T4). All assessments were performed approximately within 2 weeks post-chemotherapy. Subjective and objective cognitive function were assessed using Functional Assessment of Cancer Therapy-Cognitive (version 3) and Headminder™.RESULTS:
A total of 166 BCPs were recruited, of whom 131 completed assessment at all time points. Using the minimal clinically important difference of Functional Assessment of Cancer Therapy-Cognitive, 5 distinct cognitive trajectories were established. Of the 131 patients, 70 (53.4%) did not report any clinically significant cognitive impairment. Twenty-one (16.0%) patients reported acute cognitive changes during chemotherapy (T2 and/or T3) but not at T4. Forty patients (30.5%) reported clinically significant cognitive impairment at T4, of whom 18 did not report any cognitive impairment at earlier time points. Fifteen (11.5%) patients reported persistent cognitive impairment throughout all time points, while 7 (5.3%) patients reported intermittent cognitive impairment at T2 and T4 but not at T3.CONCLUSION:
This is the first study to establish the existence of heterogeneous cognitive trajectories based on clinically significant thresholds of self-perceived cognitive impairment. The findings have important implications on the window for screening and management of post-chemotherapy cognitive impairment.Palavras-chave
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MEDLINE
Assunto principal:
Autoimagem
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Neoplasias da Mama
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Povo Asiático
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Disfunção Cognitiva
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Sobreviventes de Câncer
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article