Evaluation of the CellaVision DM96 advanced RBC application for screening and follow-up of malaria infection.
Diagn Microbiol Infect Dis
; 90(4): 253-256, 2018 Apr.
Article
em En
| MEDLINE
| ID: mdl-29317138
ABSTRACT
CellaVision DM96 is a digital cell morphology system for automated classification of white and red blood cells. CellaVision Advanced RBC application (ARBCA) pre-classifies RBC in 21 categories, including parasitized RBC, and allows re-classification by the operator. In this study, the performance of the software for detection of malaria and calculation of parasitemia was evaluated and compared to microscopy (n=40). For CellaVision, both pre- and post-reclassification results were evaluated. Sensitivity was moderate, even post-reclassification (72%), due to low numbers of analyzed RBC and limited resolution of photographs. CellaVision results correlated with microscopy according to Passing-Bablok analysis, with slightly lower values for CellaVision. Within-run, between-run and inter-observer variability were acceptable. The low sensitivity of CellaVision ARBCA precludes its use as a screening technique for malaria. However, due to its good correlation with microscopy and short turn-around-times, it may be useful in follow-up of parasitemia. Larger studies are required to confirm these findings.
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MEDLINE
Assunto principal:
Programas de Rastreamento
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Técnicas Citológicas
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Testes Diagnósticos de Rotina
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Eritrócitos
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Automação Laboratorial
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Malária
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article