Dissecting Degradomes: Analysis of Protease-Coding Genes.
Methods Mol Biol
; 1731: 1-13, 2018.
Article
em En
| MEDLINE
| ID: mdl-29318538
ABSTRACT
Proteases constitute up to 3% of all protein-coding genes in a vertebrate genome and participate in numerous physiological and pathological processes. The characterization of the degradome of one organism, the set of all genes encoding proteolytic enzymes, and the comparison to the degradome of other species have proved useful to identify genetic differences that are helpful to elucidate the molecular basis of diverse biological processes, the different susceptibility to disease, and the evolution of the structure and function of proteases. Here we describe the main procedures involved in the characterization of the degradome of an organism for which its genome sequence is available.
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Base de dados:
MEDLINE
Assunto principal:
Evolução Molecular
/
Biologia Computacional
/
Genômica
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article