Alkene functionalization for the stereospecific synthesis of substituted aziridines by visible-light photoredox catalysis.
Chem Commun (Camb)
; 54(16): 1948-1951, 2018 Feb 20.
Article
em En
| MEDLINE
| ID: mdl-29326995
ABSTRACT
A novel strategy involving visible-light-induced functionalization of alkenes for the synthesis of substituted aziridines was developed. The readily prepared N-protected 1-aminopyridinium salts were used for the generation of N-centered radicals. This approach allowed the synthesis of aziridines bearing various functional groups with excellent diastereoselectivity under mild conditions. Moreover, this protocol was successfully applied to prepare structurally diverse nitrogen-containing frameworks.
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MEDLINE
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En
Ano de publicação:
2018
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Article