Tau Deficiency Down-Regulated Transcription Factor Orthodenticle Homeobox 2 Expression in the Dopaminergic Neurons in Ventral Tegmental Area and Caused No Obvious Motor Deficits in Mice.
Neuroscience
; 373: 52-59, 2018 03 01.
Article
em En
| MEDLINE
| ID: mdl-29337233
ABSTRACT
Tau protein participates in microtubule stabilization, axonal transport, and protein trafficking. Loss of normal tau function will exert a negative effect. However, current knowledge on the impact of tau deficiency on the motor behavior and related neurobiological changes is controversial. In this study, we examined motor functions and analyzed several proteins implicated in the maintenance of midbrain dopaminergic (DA) neurons (mDANs) function of adult and aged tau+/+, tau+/-, tau-/- mice. We found tau deficiency could not induce significant motor disorders. However, we discovered lower expression levels of transcription factors Orthodenticle homeobox 2 (OTX2) of mDANs in older aged mice. Compared with age-matched tau+/+ mice, there were 54.1% lower (pâ¯=â¯0.0192) OTX2 protein (OTX2-fluorescence intensity) in VTA DA neurons of tau+/- mice and 43.6% lower (pâ¯=â¯0.0249) OTX2 protein in VTA DA neurons of tau-/- mice at 18â¯months old. Combined with the relevant reports, our results suggested that tau deficiency alone might not be enough to mimic the pathology of Parkinson's disease. However, OTX2 down-regulation indicates that mDANs of tau-deficient mice will be more sensitive to toxic damage from MPTP.
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MEDLINE
Assunto principal:
Proteínas tau
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Área Tegmentar Ventral
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Fatores de Transcrição Otx
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Neurônios Dopaminérgicos
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Atividade Motora
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article