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Impaired DNA damage response signaling by FUS-NLS mutations leads to neurodegeneration and FUS aggregate formation.
Naumann, Marcel; Pal, Arun; Goswami, Anand; Lojewski, Xenia; Japtok, Julia; Vehlow, Anne; Naujock, Maximilian; Günther, René; Jin, Mengmeng; Stanslowsky, Nancy; Reinhardt, Peter; Sterneckert, Jared; Frickenhaus, Marie; Pan-Montojo, Francisco; Storkebaum, Erik; Poser, Ina; Freischmidt, Axel; Weishaupt, Jochen H; Holzmann, Karlheinz; Troost, Dirk; Ludolph, Albert C; Boeckers, Tobias M; Liebau, Stefan; Petri, Susanne; Cordes, Nils; Hyman, Anthony A; Wegner, Florian; Grill, Stephan W; Weis, Joachim; Storch, Alexander; Hermann, Andreas.
Afiliação
  • Naumann M; Department of Neurology, Technische Universität Dresden, 01307, Dresden, Germany.
  • Pal A; Department of Neurology, Technische Universität Dresden, 01307, Dresden, Germany.
  • Goswami A; Institute of Neuropathology, RWTH Aachen University Hospital, Pauwelsstrasse-30, 52074, Aachen, Germany.
  • Lojewski X; Department of Neurology, Technische Universität Dresden, 01307, Dresden, Germany.
  • Japtok J; Department of Neurology, Technische Universität Dresden, 01307, Dresden, Germany.
  • Vehlow A; OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, 01307, Germany.
  • Naujock M; German Cancer Consortium (DKTK), partner site Dresden, and German Cancer Research Center (DKFZ), 69192, Heidelberg, Germany.
  • Günther R; Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiooncology-OncoRay, 01328, Dresden, Germany.
  • Jin M; Department of Neurology, Hannover Medical School, 30625, Hannover, Germany.
  • Stanslowsky N; CNS Research Department, Boehringer Ingelheim Pharma GmbH & Co. KG, Binger Strasse 173, 55216, Ingelheim am Rhein, Germany.
  • Reinhardt P; Department of Neurology, Technische Universität Dresden, 01307, Dresden, Germany.
  • Sterneckert J; Department of Neurology, Technische Universität Dresden, 01307, Dresden, Germany.
  • Frickenhaus M; Department of Neurology, Hannover Medical School, 30625, Hannover, Germany.
  • Pan-Montojo F; Center for Regenerative Therapies Dresden (CRTD), Technische Universität Dresden, 01307, Dresden, Germany.
  • Storkebaum E; AbbVie Deutschland GmbH & Co. KG, 67061, Ludwigshafen, Germany.
  • Poser I; Center for Regenerative Therapies Dresden (CRTD), Technische Universität Dresden, 01307, Dresden, Germany.
  • Freischmidt A; Molecular Neurogenetics Laboratory, Max Planck Institute for Molecular Biomedicine, 48149, Münster, Germany.
  • Weishaupt JH; Faculty of Medicine, University of Münster, 48149, Münster, Germany.
  • Holzmann K; Department of Neurology, Klinikum der Universität München, and Munich Cluster for Systems Neurology, SyNergy, 81377, Munich, Germany.
  • Troost D; Molecular Neurogenetics Laboratory, Max Planck Institute for Molecular Biomedicine, 48149, Münster, Germany.
  • Ludolph AC; Faculty of Medicine, University of Münster, 48149, Münster, Germany.
  • Boeckers TM; Department of Molecular Neurobiology, Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands.
  • Liebau S; Max Planck Institute of Molecular Cell Biology and Genetics, 01307, Dresden, Germany.
  • Petri S; Department of Neurology, University Ulm, 89081, Ulm, Germany.
  • Cordes N; Department of Neurology, University Ulm, 89081, Ulm, Germany.
  • Hyman AA; Genomics-Core Facility, University Hospital Ulm, Centre for Biomedical Research, 89081, Ulm, Germany.
  • Wegner F; Division of Neuropathology, Department of Pathology, Academic Medical Centre, 1105 AZ, Amsterdam, The Netherlands.
  • Grill SW; Department of Neurology, University Ulm, 89081, Ulm, Germany.
  • Weis J; Institute of Anatomy and Cell Biology, University of Ulm, 89081, Ulm, Germany.
  • Storch A; Institute of Neuroanatomy & Developmental Biology, Eberhard Karls University of Tübingen, 72074, Tübingen, Germany.
  • Hermann A; Department of Neurology, Hannover Medical School, 30625, Hannover, Germany.
Nat Commun ; 9(1): 335, 2018 01 23.
Article em En | MEDLINE | ID: mdl-29362359
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dano ao DNA / Proteína FUS de Ligação a RNA / Agregação Patológica de Proteínas / Esclerose Lateral Amiotrófica / Neurônios Motores / Mutação Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dano ao DNA / Proteína FUS de Ligação a RNA / Agregação Patológica de Proteínas / Esclerose Lateral Amiotrófica / Neurônios Motores / Mutação Idioma: En Ano de publicação: 2018 Tipo de documento: Article