Functional characterization of naturally occurring genetic variations of the human guanine-rich RNA sequence binding factor 1 (GRSF1).

Sofi, Sajad; Fitzgerald, Julia C; Jähn, Désirée; Dumoulin, Bernhard; Stehling, Sabine; Kuhn, Hartmut; Ufer, Christoph

Sofi, Sajad; Fitzgerald, Julia C; Jähn, Désirée; Dumoulin, Bernhard; Stehling, Sabine; Kuhn, Hartmut; Ufer, Christoph.

Afiliação

Sofi S; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Institute of Biochemistry, Chariteplatz 1, CCO-Building, Virchowweg 6, D-10117 Berlin, Germany.
Fitzgerald JC; Functional Neurogenomics Laboratory, Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, Centre for Integrative Neuroscience (CIN), the German Centre For Neurodegenerative Diseases (DZNE), University of Tuebingen, Otfried-Mueller-Strasse 27, D-72075 Tuebingen, Ger
Jähn D; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Institute of Biochemistry, Chariteplatz 1, CCO-Building, Virchowweg 6, D-10117 Berlin, Germany.
Dumoulin B; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Institute of Biochemistry, Chariteplatz 1, CCO-Building, Virchowweg 6, D-10117 Berlin, Germany.
Stehling S; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Institute of Biochemistry, Chariteplatz 1, CCO-Building, Virchowweg 6, D-10117 Berlin, Germany.
Kuhn H; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Institute of Biochemistry, Chariteplatz 1, CCO-Building, Virchowweg 6, D-10117 Berlin, Germany.
Ufer C; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Institute of Biochemistry, Chariteplatz 1, CCO-Building, Virchowweg 6, D-10117 Berlin, Germany. Electronic address: christoph.ufer@charite.de.

Biochim Biophys Acta Gen Subj ; 1862(4): 866-876, 2018 Apr.

Article em En | MEDLINE | ID: mdl-29366917

Assuntos

Motivos de Aminoácidos/genética; Mutação; Proteínas de Ligação a Poli(A)/genética; Sequência de Aminoácidos; Sítios de Ligação; Humanos; Cinética; Modelos Moleculares; Proteínas de Ligação a Poli(A)/química; Proteínas de Ligação a Poli(A)/metabolismo; Ligação Proteica; Domínios Proteicos; RNA/química; RNA/genética; RNA/metabolismo; Homologia de Sequência de Aminoácidos

Palavras-chave

Genetic variation; RNA recognition motif; RNA-binding; Thermostability; hnRNP F/H

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Motivos de Aminoácidos / Proteínas de Ligação a Poli(A) / Mutação Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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