Opinion: Making Inactivated and Subunit-Based Vaccines Work.
Viral Immunol
; 31(2): 150-158, 2018 03.
Article
em En
| MEDLINE
| ID: mdl-29369750
ABSTRACT
Empirically derived vaccines have in the past relied on the isolation and growth of disease-causing microorganisms that are then inactivated or attenuated before being administered. This is often done without prior knowledge of the mechanisms involved in conferring protective immunity. Recent advances in scientific technologies and in our knowledge of how protective immune responses are induced enable us to rationally design novel and safer vaccination strategies. Such advances have accelerated the development of inactivated whole-organism- and subunit-based vaccines. In this review, we discuss ideal attributes and criteria that need to be considered for the development of vaccines and some existing vaccine platforms. We focus on inactivated vaccines against influenza virus and ways by which vaccine efficacy can be improved with the use of adjuvants and Toll-like receptor-2 signaling.
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Base de dados:
MEDLINE
Assunto principal:
Vacinas contra Influenza
/
Descoberta de Drogas
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article