An Induced Pluripotent Stem Cell Patient Specific Model of Complement Factor H (Y402H) Polymorphism Displays Characteristic Features of Age-Related Macular Degeneration and Indicates a Beneficial Role for UV Light Exposure.

Anderson, Graham; Bagnaninchi, Pierre; McLeod, Andrew; Dhillon, Baljean

Anderson, Graham; Bagnaninchi, Pierre; McLeod, Andrew; Dhillon, Baljean.

Afiliação

Anderson G; University of Edinburgh College of Medicine and Veterinary Medicine - MRC Centre for Regenerative Medicine, Edinburgh, United Kingdom.
Bagnaninchi P; University of Edinburgh College of Medicine and Veterinary Medicine - MRC Centre for Regenerative Medicine, Edinburgh, United Kingdom.
McLeod A; University of Edinburgh School of GeoSciences, Edinburgh, United Kingdom.
Dhillon B; University of Edinburgh College of Medicine and Veterinary Medicine - Centre for Clinical Brain Sciences, Edinburgh, United Kingdom NHS Lothian - Clinical Opthalmology, Edinburgh, United Kingdom.

Stem Cells ; 36(4): 626, 2018 04.

Article em En | MEDLINE | ID: mdl-29377444

Assuntos

Células-Tronco Pluripotentes Induzidas/metabolismo; Degeneração Macular; Modelos Biológicos; Polimorfismo Genético; Raios Ultravioleta; Fator H do Complemento/genética; Fator H do Complemento/metabolismo; Humanos; Células-Tronco Pluripotentes Induzidas/patologia; Degeneração Macular/genética; Degeneração Macular/metabolismo; Degeneração Macular/patologia

Palavras-chave

AMD; RPE; UV Exposure; iPS

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Polimorfismo Genético / Raios Ultravioleta / Células-Tronco Pluripotentes Induzidas / Degeneração Macular / Modelos Biológicos Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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