Coexistence of t(2;14;11)(p16.1;q32;q23) and t(14;19)(q32;q13.3) chromosome translocations in a patient with chronic lymphocytic leukemia: A case report.
Medicine (Baltimore)
; 96(51): e9169, 2017 Dec.
Article
em En
| MEDLINE
| ID: mdl-29390452
ABSTRACT
RATIONALE With combination of multiple techniques, we have successfully characterized unique, complex chromosomal changes in a patient with chronic lymphocytic leukemia (CLL), a lymphoproliferative disorder. DIAGNOSES The diagnosis was based on white blood cell, flow cytometry, and immunophenotypes and confirmed by karyotype, fluorescence in situ hybridization, and array comparative genomic hybridization from the patient's blood culture. INTERVENTIONS:
The patient was given fludarabine, cyclophosphamide and rituximab (FCR) for 6 cycles.OUTCOMES:
After completion of 6 cycles of FCR, the computed tomography scans of the neck/chest/abdomen/pelvic showed that the patient in CR. During the 10-month follow-up, the patient's clinical course remained uneventful. LESSONS The translocation t(14;19) identified in this patient is a recurrent translocation found in patients with chronic B-cell lymphoproliferative disorders and the 3-way translocation involving chromosomes 2, 14, and 11 may play a role as an enhancer.
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Base de dados:
MEDLINE
Assunto principal:
Translocação Genética
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Cromossomos Humanos Par 2
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Cromossomos Humanos Par 11
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Cromossomos Humanos Par 14
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Leucemia Linfocítica Crônica de Células B
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article