Extracts from guava fruit protect renal tubular endothelial cells against acetaminopheninduced cytotoxicity.
Mol Med Rep
; 17(4): 5544-5551, 2018 04.
Article
em En
| MEDLINE
| ID: mdl-29393462
ABSTRACT
Acetaminophen (APAP) is an analgesic and antipyretic agent primarily used in the clinical setting. However, high doses of APAP can cause oxidative stress. Guavas have been reported to provide antiinflammatory, antimicrobial, antioxidative and antidiarrheal functions. In addition, guavas have been reported to prevent renal damage due to progression of diabetes mellitus. Therefore, the aim of the present study was to investigate whether guavas can reduce APAPinduced renal cell damage. In the present study, extracts from guavas were obtained and added to APAPtreated renal tubular endothelial cells. The present results demonstrated that APAP induces cytotoxicity in renal tubular endothelial cells, while guava extracts inhibited this cytotoxicity. In addition, the study demonstrated that the protective effects of guava extracts against APAPinduced cytotoxicity may be associated with inhibition of oxidative stress and caspase3 activation.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Extratos Vegetais
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Substâncias Protetoras
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Psidium
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Células Epiteliais
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Frutas
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Túbulos Renais
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Acetaminofen
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article