Intracerebral efficacy and tolerance of nivolumab in non-small-cell lung cancer patients with brain metastases.
Lung Cancer
; 116: 62-66, 2018 02.
Article
em En
| MEDLINE
| ID: mdl-29413052
ABSTRACT
OBJECTIVES:
Although nivolumab has shown efficacy against non-small-cell lung cancers (NSCLCs), patients with active brain metastases (BMs) were excluded from pivotal clinical trials. Hence, data regarding nivolumab intracerebral activity and safety in NSCLC patients with BMs are scarce. MATERIALS ANDMETHODS:
We conducted a retrospective multicenter study on NSCLC patients with BMs treated with nivolumab. The primary endpoint was intracerebral objective response rate (IORR), according to RECIST criteria. Secondary endpoints included intracerebral control rate, intracerebral and general progression-free survival (PFS), overall survival (OS) and tolerance. RESULTS ANDCONCLUSION:
Forty-three patients were included. BMs were locally pretreated in 34 (79%) patients and active in 16 (37%) patients. Median follow-up was 5.7 (95% CI 2.7-8.4) months. IORR and extracerebral response rate were, respectively, 9% (95% CI 3-23%) and 11% (95% CI 4-26%). Intracerebral control rate was 51% (95% CI 37-66%). Median intracerebral and general PFS lasted 3.9 (95% CI 2.8-11.1) and 2.8 (95% CI 1.8-4.6) months, respectively. Median OS was 7.5 (95% CI 5.6-not reached) months. Five neurological adverse events occurred, including 1 grade-4 transient ischemic attack of uncertain imputability and 1 grade-3 neurological deficit; neither required nivolumab discontinuation. Nivolumab intracerebral activity was similar to its reported extracerebral efficacy, with an acceptable safety profile. Prospective and controlled data are needed to determine nivolumab's place in treatment of NSCLC patients with BMs.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Encefálicas
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Carcinoma Pulmonar de Células não Pequenas
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Nivolumabe
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Neoplasias Pulmonares
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article