In vitro and in vivo anti-leukemic effects of cladoloside C2 are mediated by activation of Fas/ceramide synthase 6/p38 kinase/c-Jun NH2-terminal kinase/caspase-8.

Yun, Seong-Hoon; Sim, Eun-Hye; Han, Sang-Heum; Kim, Tae-Rang; Ju, Mi-Ha; Han, Jin-Yeong; Jeong, Jin-Sook; Kim, Sung-Hyun; Silchenko, Alexandra S; Stonik, Valentin A; Park, Joo-In

In vitro and in vivo anti-leukemic effects of cladoloside C₂ are mediated by activation of Fas/ceramide synthase 6/p38 kinase/c-Jun NH₂-terminal kinase/caspase-8.

Yun, Seong-Hoon; Sim, Eun-Hye; Han, Sang-Heum; Kim, Tae-Rang; Ju, Mi-Ha; Han, Jin-Yeong; Jeong, Jin-Sook; Kim, Sung-Hyun; Silchenko, Alexandra S; Stonik, Valentin A; Park, Joo-In.

Afiliação

Yun SH; Department of Biochemistry, Dong-A University College of Medicine, Busan, South Korea.
Sim EH; Department of Biochemistry, Dong-A University College of Medicine, Busan, South Korea.
Han SH; Department of Biochemistry, Dong-A University College of Medicine, Busan, South Korea.
Kim TR; Department of Biochemistry, Dong-A University College of Medicine, Busan, South Korea.
Ju MH; Department of Pathology, Dong-A University College of Medicine, Busan, South Korea.
Han JY; Department of Laboratory Medicine, Dong-A University College of Medicine, Busan, South Korea.
Jeong JS; Department of Pathology, Dong-A University College of Medicine, Busan, South Korea.
Kim SH; Department of Internal Medicine, Dong-A University College of Medicine, Busan, South Korea.
Silchenko AS; G.B. Elyakov Pacific Institute of Bio-organic Chemistry, Far-Eastern Branch of the Russian Academy of Sciences, Vladivostok, Russia.
Stonik VA; G.B. Elyakov Pacific Institute of Bio-organic Chemistry, Far-Eastern Branch of the Russian Academy of Sciences, Vladivostok, Russia.
Park JI; Department of Biochemistry, Dong-A University College of Medicine, Busan, South Korea.