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Design, synthesis and pharmacological evaluation of N-benzyl-piperidinyl-aryl-acylhydrazone derivatives as donepezil hybrids: Discovery of novel multi-target anti-alzheimer prototype drug candidates.
Dias Viegas, Flávia Pereira; de Freitas Silva, Matheus; Divino da Rocha, Miguel; Castelli, Maísa Rosa; Riquiel, Mariana Máximo; Machado, Rafael Pereira; Vaz, Sarah Macedo; Simões de Lima, Laís Medeiros; Mancini, Karla Cristine; Marques de Oliveira, Patrícia Cruz; Morais, Élida Parreira; Gontijo, Vanessa Silva; da Silva, Fernanda Motta R; D'Alincourt da Fonseca Peçanha, Dora; Castro, Newton Gonçalves; Neves, Gilda A; Giusti-Paiva, Alexandre; Vilela, Fabiana Cardoso; Orlandi, Lidiane; Camps, Ihosvany; Veloso, Márcia Paranho; Leomil Coelho, Luis Felipe; Ionta, Marisa; Ferreira-Silva, Guilherme Álvaro; Pereira, Rodrigo Machado; Dardenne, Laurent E; Guedes, Isabella Alvim; de Oliveira Carneiro Junior, Wellerson; Quaglio Bellozi, Paula Maria; Pinheiro de Oliveira, Antônio Carlos; Ferreira, Fábio Furlan; Pruccoli, Letizia; Tarozzi, Andrea; Viegas, Claudio.
Afiliação
  • Dias Viegas FP; Institute of Chemistry, Laboratory of Research on Medicinal Chemistry, Federal University of Alfenas, MG 37133-840, Brazil.
  • de Freitas Silva M; Institute of Chemistry, Laboratory of Research on Medicinal Chemistry, Federal University of Alfenas, MG 37133-840, Brazil.
  • Divino da Rocha M; Institute of Chemistry, Laboratory of Research on Medicinal Chemistry, Federal University of Alfenas, MG 37133-840, Brazil.
  • Castelli MR; Institute of Chemistry, Laboratory of Research on Medicinal Chemistry, Federal University of Alfenas, MG 37133-840, Brazil.
  • Riquiel MM; Institute of Chemistry, Laboratory of Research on Medicinal Chemistry, Federal University of Alfenas, MG 37133-840, Brazil.
  • Machado RP; Institute of Chemistry, Laboratory of Research on Medicinal Chemistry, Federal University of Alfenas, MG 37133-840, Brazil.
  • Vaz SM; Institute of Chemistry, Laboratory of Research on Medicinal Chemistry, Federal University of Alfenas, MG 37133-840, Brazil.
  • Simões de Lima LM; Institute of Chemistry, Laboratory of Research on Medicinal Chemistry, Federal University of Alfenas, MG 37133-840, Brazil.
  • Mancini KC; Institute of Chemistry, Laboratory of Research on Medicinal Chemistry, Federal University of Alfenas, MG 37133-840, Brazil.
  • Marques de Oliveira PC; Institute of Chemistry, Laboratory of Research on Medicinal Chemistry, Federal University of Alfenas, MG 37133-840, Brazil.
  • Morais ÉP; Institute of Chemistry, Laboratory of Research on Medicinal Chemistry, Federal University of Alfenas, MG 37133-840, Brazil.
  • Gontijo VS; Institute of Chemistry, Laboratory of Research on Medicinal Chemistry, Federal University of Alfenas, MG 37133-840, Brazil.
  • da Silva FMR; Laboratory of Molecular Pharmacology, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, RJ 21941-902, Brazil.
  • D'Alincourt da Fonseca Peçanha D; Laboratory of Molecular Pharmacology, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, RJ 21941-902, Brazil.
  • Castro NG; Laboratory of Molecular Pharmacology, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, RJ 21941-902, Brazil.
  • Neves GA; Laboratory of Molecular Pharmacology, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, RJ 21941-902, Brazil.
  • Giusti-Paiva A; Institute of Biomedical Sciences, Federal University of Minas Gerais, MG 37130-000, Brazil.
  • Vilela FC; Institute of Biomedical Sciences, Federal University of Minas Gerais, MG 37130-000, Brazil.
  • Orlandi L; Institute of Biomedical Sciences, Federal University of Minas Gerais, MG 37130-000, Brazil.
  • Camps I; Institute of Exact Sciences, Federal University of Alfenas, MG 37130-000, Brazil.
  • Veloso MP; Faculty of Pharmacy, Federal University of Alfenas, MG 37130-000, Brazil.
  • Leomil Coelho LF; Laboratory of Vaccines, Institute of Biomedical Sciences, Federal University of Alfenas, MG 37130-000, Brazil.
  • Ionta M; Institute of Biomedical Sciences, Federal University of Minas Gerais, MG 37130-000, Brazil.
  • Ferreira-Silva GÁ; Institute of Biomedical Sciences, Federal University of Minas Gerais, MG 37130-000, Brazil.
  • Pereira RM; Institute of Biomedical Sciences, Federal University of Minas Gerais, MG 37130-000, Brazil.
  • Dardenne LE; National Laboratory of Computational Sciences, Petrópolis, RJ 25651-075, Brazil.
  • Guedes IA; National Laboratory of Computational Sciences, Petrópolis, RJ 25651-075, Brazil.
  • de Oliveira Carneiro Junior W; Institute of Biological Sciences, Federal University of Minas Gerais, MG 31270-901, Brazil.
  • Quaglio Bellozi PM; Institute of Biological Sciences, Federal University of Minas Gerais, MG 31270-901, Brazil.
  • Pinheiro de Oliveira AC; Institute of Biological Sciences, Federal University of Minas Gerais, MG 31270-901, Brazil.
  • Ferreira FF; Centre of Natural and Human Sciences, Federal University of ABC, Santo André, SP 09210-580, Brazil.
  • Pruccoli L; Department for Life Quality Studies, Alma Mater Studiorum-University of Bologna, Rimini 47921, Italy.
  • Tarozzi A; Department for Life Quality Studies, Alma Mater Studiorum-University of Bologna, Rimini 47921, Italy.
  • Viegas C; Institute of Chemistry, Laboratory of Research on Medicinal Chemistry, Federal University of Alfenas, MG 37133-840, Brazil. Electronic address: cvjviegas@gmail.com.
Eur J Med Chem ; 147: 48-65, 2018 Mar 10.
Article em En | MEDLINE | ID: mdl-29421570
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piperidinas / Anti-Inflamatórios não Esteroides / Inibidores da Colinesterase / Fármacos Neuroprotetores / Descoberta de Drogas / Hidrazonas / Indanos Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piperidinas / Anti-Inflamatórios não Esteroides / Inibidores da Colinesterase / Fármacos Neuroprotetores / Descoberta de Drogas / Hidrazonas / Indanos Idioma: En Ano de publicação: 2018 Tipo de documento: Article