5-Hydroxymethylcytosine preferentially targets genes upregulated in isocitrate dehydrogenase 1 mutant high-grade glioma.

Glowacka, Wioletta K; Jain, Harshika; Okura, Makiko; Maimaitiming, Abulizi; Mamatjan, Yasin; Nejad, Romina; Farooq, Hamza; Taylor, Michael D; Aldape, Kenneth; Kongkham, Paul

Glowacka, Wioletta K; Jain, Harshika; Okura, Makiko; Maimaitiming, Abulizi; Mamatjan, Yasin; Nejad, Romina; Farooq, Hamza; Taylor, Michael D; Aldape, Kenneth; Kongkham, Paul.

Afiliação

Glowacka WK; MacFeeters-Hamilton Centre for Neuro-Oncology Research, University Health Network, Toronto, Canada.
Jain H; MacFeeters-Hamilton Centre for Neuro-Oncology Research, University Health Network, Toronto, Canada.
Okura M; MacFeeters-Hamilton Centre for Neuro-Oncology Research, University Health Network, Toronto, Canada.
Maimaitiming A; Division of Respiratory Medicine, Faculty of Medicine, Juntendo University, Tokyo, Japan.
Mamatjan Y; MacFeeters-Hamilton Centre for Neuro-Oncology Research, University Health Network, Toronto, Canada.
Nejad R; MacFeeters-Hamilton Centre for Neuro-Oncology Research, University Health Network, Toronto, Canada.
Farooq H; MacFeeters-Hamilton Centre for Neuro-Oncology Research, University Health Network, Toronto, Canada.
Taylor MD; Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Canada.
Aldape K; Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Canada.
Kongkham P; Division of Neurosurgery, The Hospital for Sick Children, Toronto, Canada.

Acta Neuropathol ; 135(4): 617-634, 2018 04.

Article em En | MEDLINE | ID: mdl-29428975

Assuntos

5-Metilcitosina/análogos & derivados; Neoplasias Encefálicas/metabolismo; Glioma/metabolismo; Isocitrato Desidrogenase/genética; 5-Metilcitosina/metabolismo; Adulto; Idoso; Neoplasias Encefálicas/genética; Neoplasias Encefálicas/patologia; Estudos de Coortes; Metilação de DNA; Feminino; Regulação Neoplásica da Expressão Gênica; Glioma/genética; Glioma/patologia; Humanos; Masculino; Pessoa de Meia-Idade; Gradação de Tumores; RNA Mensageiro/metabolismo; Regulação para Cima

Palavras-chave

5-Hydroxymethylcytosine (5hmC); EPIC BeadChip; Enhancer; G-CIMP; Glioma; IDH1 mutation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / 5-Metilcitosina / Glioma / Isocitrato Desidrogenase Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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