S-Nitrosylation in Regulation of Inflammation and Cell Damage.
Curr Drug Targets
; 19(15): 1831-1838, 2018.
Article
em En
| MEDLINE
| ID: mdl-29437005
ABSTRACT
BACKGROUND:
Cell signaling through nitric oxide (NO) is a multifaceted mechanism, which regulates metabolic activities and fate in different tissues. The peroxynitrite (ONOO-) formed as reaction product of nitric oxide radical and superoxide interacts with cell membrane phospholipids and proteins causing damage.OBJECTIVE:
The reaction kinetics to form nitrotyrosine (ONOO-tyrosine) and/or nitrosylated cysteine (ONOO-cysteine) in protein molecules during posttranslational modification and nitration of lipids are therefore critical in determining cells' signaling mechanism for survival or apoptosis.RESULTS:
The nitrosylation was found to modulate GPCRs and activation of guanylate cyclase as well as regulate NF-κB activation. The recent findings have shown the neuroprotective effects of S- nitrosylation, though mechanism is unclear.CONCLUSION:
While keeping the background in mind, we address here the biological function of NO derivatives in medicine. We target four known compounds SNAP, SIN- 1 chloride, SNP and GSNO to understand the effect of NO in different tissues. Here we analyze the existing findings to assess therapeutic relevance of NO-signaling during inflammation, vasodilation and tolerance.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
NF-kappa B
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Receptores Acoplados a Proteínas G
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Guanilato Ciclase
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Inflamação
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Óxido Nítrico
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article