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S-Nitrosylation in Regulation of Inflammation and Cell Damage.
Dasgupta, Subhajit; Gomez, Jenny-Jaramillo; Singh, Inderjit; Khan, Mushfiquddin.
Afiliação
  • Dasgupta S; Medical University of South Carolina, Charleston, SC 29425, United States.
  • Gomez JJ; Department of Physical Sciences, Chemistry, Trident Technical College, Charleston, South Carolina, United States.
  • Singh I; Medical University of South Carolina, Charleston, SC 29425, United States.
  • Khan M; Medical University of South Carolina, Charleston, SC 29425, United States.
Curr Drug Targets ; 19(15): 1831-1838, 2018.
Article em En | MEDLINE | ID: mdl-29437005
ABSTRACT

BACKGROUND:

Cell signaling through nitric oxide (NO) is a multifaceted mechanism, which regulates metabolic activities and fate in different tissues. The peroxynitrite (ONOO-) formed as reaction product of nitric oxide radical and superoxide interacts with cell membrane phospholipids and proteins causing damage.

OBJECTIVE:

The reaction kinetics to form nitrotyrosine (ONOO-tyrosine) and/or nitrosylated cysteine (ONOO-cysteine) in protein molecules during posttranslational modification and nitration of lipids are therefore critical in determining cells' signaling mechanism for survival or apoptosis.

RESULTS:

The nitrosylation was found to modulate GPCRs and activation of guanylate cyclase as well as regulate NF-κB activation. The recent findings have shown the neuroprotective effects of S- nitrosylation, though mechanism is unclear.

CONCLUSION:

While keeping the background in mind, we address here the biological function of NO derivatives in medicine. We target four known compounds SNAP, SIN- 1 chloride, SNP and GSNO to understand the effect of NO in different tissues. Here we analyze the existing findings to assess therapeutic relevance of NO-signaling during inflammation, vasodilation and tolerance.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: NF-kappa B / Receptores Acoplados a Proteínas G / Guanilato Ciclase / Inflamação / Óxido Nítrico Idioma: En Ano de publicação: 2018 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: NF-kappa B / Receptores Acoplados a Proteínas G / Guanilato Ciclase / Inflamação / Óxido Nítrico Idioma: En Ano de publicação: 2018 Tipo de documento: Article