Prediction of outcome in asphyxiated newborns treated with hypothermia: Is a MRI scoring system described before the cooling era still useful?
Eur J Paediatr Neurol
; 22(3): 387-395, 2018 May.
Article
em En
| MEDLINE
| ID: mdl-29439909
ABSTRACT
AIM:
To determine whether an MRI scoring system, which was validated in the pre-cooling era, can still predict the neurodevelopmental outcome of asphyxiated newborns treated with hypothermia at 2 years of age. PATIENTS ANDMETHOD:
We conducted a retrospective cohort study of asphyxiated newborns treated with hypothermia. An MRI scoring system, which was validated in the pre-cooling era, was used to grade the severity of brain injury on the neonatal brain MRI. Their neurodevelopment was assessed around 2 years of age; adverse outcome included cerebral palsy, global developmental delay, and/or epilepsy.RESULTS:
One hundred and sixty-nine newborns were included. Among the 131 newborns who survived and had a brain MRI during the neonatal period, 92% were evaluated around 2 years of age or later. Of these newborns, 37% displayed brain injury, and 23% developed an adverse outcome. Asphyxiated newborns treated with hypothermia who had an adverse outcome had a significantly higher MRI score (p <0.001) compared to those without an adverse outcome.CONCLUSION:
An MRI scoring system that was validated before the cooling era is still able to reliably differentiate which of the asphyxiated newborns treated with hypothermia were more prone to develop an adverse outcome around 2 years of age.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Asfixia Neonatal
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Imageamento por Ressonância Magnética
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Hipotermia Induzida
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article