Tough Composite Hydrogels with High Loading and Local Release of Biological Drugs.
Adv Healthc Mater
; 7(9): e1701393, 2018 05.
Article
em En
| MEDLINE
| ID: mdl-29441702
ABSTRACT
Hydrogels are under active development for controlled drug delivery, but their clinical translation is limited by low drug loading capacity, deficiencies in mechanical toughness and storage stability, and poor control over the drug release that often results in burst release and short release duration. This work reports a design of composite clay hydrogels, which simultaneously achieve a spectrum of mechanical, storage, and drug loading/releasing properties to address the critical needs from translational perspectives. The clay nanoparticles provide large surface areas to adsorb biological drugs, and assemble into microparticles that are physically trapped within and toughen hydrogel networks. The composite hydrogels demonstrate feasibility of storage, and extended release of large quantities of an insulin-like growth factor-1 mimetic protein (8 mg mL-1 ) over four weeks. The release rate is primarily governed by ionic exchange and can be upregulated by low pH, which is typical for injured tissues. A rodent model of Achilles tendon injury is used to demonstrate that the composite hydrogels allow for highly extended and localized release of biological drugs in vivo, while demonstrating biodegradation and biocompatibility. These attributes make the composite hydrogel a promising system for drug delivery and regenerative medicine.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Tendão do Calcâneo
/
Traumatismos dos Tendões
/
Fator de Crescimento Insulin-Like I
/
Portadores de Fármacos
/
Hidrogéis
/
Materiais Biomiméticos
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article