Chiral-at-Metal Rh(III) Complex-Catalyzed Michael Addition of Pyrazolones with α,ß-Unsaturated 2-Acyl Imidazoles.
Org Lett
; 20(5): 1312-1315, 2018 03 02.
Article
em En
| MEDLINE
| ID: mdl-29446638
ABSTRACT
An efficient enantioselective conjugate addition of pyrazolones with α,ß-unsaturated 2-acyl imidazoles catalyzed by chiral-at-metal rhodium complex is reported. The corresponding adducts were obtained in good yields (85%-96%) with excellent enantioselectivities (up to >99%). This protocol exhibits extraordinary reactivity, because of the fact that a complex with as little as 0.05 molâ¯% Rh(III) can catalyze the title reaction on a gram-scale with excellent enantioselectivity.
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MEDLINE
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En
Ano de publicação:
2018
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Article