Apixaban or Rivaroxaban Versus Warfarin for Treatment of Submassive Pulmonary Embolism After Catheter-Directed Thrombolysis.
Clin Appl Thromb Hemost
; 24(6): 908-913, 2018 Sep.
Article
em En
| MEDLINE
| ID: mdl-29455567
ABSTRACT
BACKGROUND:
Little data exist on the use of direct oral anticoagulant (DOAC) factor Xa inhibitors for submassive pulmonary embolism (PE) after catheter-directed thrombolysis (CDT). The objective of this evaluation was to determine whether the transition from parenteral anticoagulation to DOACs for submassive PE after CDT would decrease hospital length of stay (LOS) compared to warfarin.METHODS:
A retrospective review of patients diagnosed with submassive PE who underwent CDT was conducted from January 1, 2012, to February 28, 2017. Hospital LOS and major and minor bleeding events were recorded during hospitalization and at 90 days.RESULTS:
Sixty-two patients met the inclusion criteria, 36 in warfarin group and 26 in the DOAC group. Overall, patients receiving rivaroxaban or apixaban had a shorter median hospital LOS compared to warfarin (4.0 vs 6.1 days, P = .002). In the multivariate regression analysis, administration of DOAC was an independent predictor of decreased hospital LOS, ß -2.1, 95% confidence interval (-3.5 to -0.7).CONCLUSION:
Among patients with submassive PE, initiation of a DOAC shortly after CDT may result in a decreased hospital LOS compared to parenterally bridged warfarin.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Embolia Pulmonar
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Pirazóis
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Piridonas
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Varfarina
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Terapia Trombolítica
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Rivaroxabana
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Tempo de Internação
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article