Evaluation of the application of high volume hemofiltration in sepsis combined with acute kidney injury.
Eur Rev Med Pharmacol Sci
; 22(3): 715-720, 2018 02.
Article
em En
| MEDLINE
| ID: mdl-29461600
ABSTRACT
OBJECTIVE:
To investigate the safety and effectiveness of the application of high-volume hemofiltration (HVHF) in children with sepsis combined with acute kidney injury. PATIENTS ANDMETHODS:
A total of 76 child patients were enrolled and randomly divided equally (n=38) into control and the observation groups respectively. The control group received conventional volume hemofiltration (the ultrafiltration rate of 35-50 ml/kg/h), and the observation group received HVHF (50-100 ml/kg/h).RESULTS:
The serum Interleukin-6 (IL-6), Tumor Necrosis Factor-a (TNF-α) and creatinine levels were significantly lower in the observation group than the control group at 6 h, 12 h, 24 h and 48 h of hemofiltration (p<0.05). The efficacy rate of treatment was improved. The mortality rate and incidence rate of complications were decreased, and the treatment course was significantly shortened (p<0.05).CONCLUSIONS:
The application of HVHF in children with sepsis combined with acute kidney injury has a better safety and effectiveness.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Hemofiltração
/
Sepse
/
Injúria Renal Aguda
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article