Dendritic Cell Migration to Skin-Draining Lymph Nodes Is Controlled by Dermatan Sulfate and Determines Adaptive Immunity Magnitude.

Nadafi, Reza; Koning, Jasper J; Veninga, Henrike; Stachtea, Xanthi N; Konijn, Tanja; Zwiers, Antonie; Malmström, Anders; den Haan, Joke M M; Mebius, Reina E; Maccarana, Marco; Reijmers, Rogier M

Nadafi, Reza; Koning, Jasper J; Veninga, Henrike; Stachtea, Xanthi N; Konijn, Tanja; Zwiers, Antonie; Malmström, Anders; den Haan, Joke M M; Mebius, Reina E; Maccarana, Marco; Reijmers, Rogier M.

Afiliação

Nadafi R; Department of Molecular Cell Biology and Immunology, VU University Medical Center, Cancer Center Amsterdam, Amsterdam, Netherlands.
Koning JJ; Department of Molecular Cell Biology and Immunology, VU University Medical Center, Cancer Center Amsterdam, Amsterdam, Netherlands.
Veninga H; Department of Molecular Cell Biology and Immunology, VU University Medical Center, Cancer Center Amsterdam, Amsterdam, Netherlands.
Stachtea XN; Department of Experimental Medical Science, Lund University, Lund, Sweden.
Konijn T; Department of Molecular Cell Biology and Immunology, VU University Medical Center, Cancer Center Amsterdam, Amsterdam, Netherlands.
Zwiers A; Department of Molecular Cell Biology and Immunology, VU University Medical Center, Cancer Center Amsterdam, Amsterdam, Netherlands.
Malmström A; Department of Experimental Medical Science, Lund University, Lund, Sweden.
den Haan JMM; Department of Molecular Cell Biology and Immunology, VU University Medical Center, Cancer Center Amsterdam, Amsterdam, Netherlands.
Mebius RE; Department of Molecular Cell Biology and Immunology, VU University Medical Center, Cancer Center Amsterdam, Amsterdam, Netherlands.
Maccarana M; Department of Experimental Medical Science, Lund University, Lund, Sweden.
Reijmers RM; Department of Molecular Cell Biology and Immunology, VU University Medical Center, Cancer Center Amsterdam, Amsterdam, Netherlands.

Front Immunol ; 9: 206, 2018.

Article em En | MEDLINE | ID: mdl-29472931

Assuntos

Imunidade Adaptativa; Movimento Celular/imunologia; Dermatan Sulfato/metabolismo; Células de Langerhans/imunologia; Linfonodos/imunologia; Animais; Biópsia; Linfócitos T CD8-Positivos/imunologia; Carboidratos Epimerases/deficiência; Carboidratos Epimerases/genética; Dermatan Sulfato/imunologia; Feminino; Células de Langerhans/metabolismo; Linfonodos/citologia; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Knockout; Modelos Animais; Pele/citologia; Pele/imunologia; Pele/patologia

Palavras-chave

Dse; EhlersDanlos syndrome; adaptive immunity; antigen; collagen; dendritic cells; dermatan sulfate epimerase; skindraining lymph node

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Movimento Celular / Células de Langerhans / Dermatan Sulfato / Imunidade Adaptativa / Linfonodos Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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